SREBF2 CLIA Kit for Human(Homo sapiens) | EIAab.comSREBF2 CLIA Kit for Human(Homo sapiens)

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SREBF2 (Gene name),

Sterol regulatory element-binding protein 2 (Protein name ), SRBP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SREBF2(BHLHD2;SREBP2);

Protein name:

Sterol regulatory element-binding protein 2(SREBP-2);

Alternative:

Sterol regulatory element-binding transcription factor 2;Class D basic helix-loop-helix protein 2(bHLHd2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts (via C-terminus domain) with RNF139.

Function:

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.

Subcellular Location:

Processed sterol regulatory element-binding protein 2 Nucleus

Protein Attributes:

Sequence length:

1141

Sequence:

50:

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350:

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1050:

1100:

1141:

QRAVLLAEAA | RTLEKVGDRR | SCNDCQQMIV | KLGGGTAIAA | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.443258

MIM:

600481

KEGG:

hsa:6721

String:

Q12772

SMR:

Q12772

Pfam:

PF00010

STRING:

9606.ENSP00000354476

Uniprot:

Q12772

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ELISA Kit for Human SREBP-2

Cat.:

E12196h

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96T

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ELISA Kit for Human SREBP-2

Cat.:

E12196r

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96T

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ELISA Kit for Human SREBP-2

Cat.:

E12196m

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Packing:

96T

CLIA Kit for Human SREBP-2

Cat.:

U12196m

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MSDS:

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Packing:

96T

CLIA Kit for Human SREBP-2

Cat.:

U12196r

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human SREBP-2

Cat.:

U12196h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human SREBP-2

Cat.:

P12196Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human SREBP-2

Protein for Human SREBP-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element."
Hua X. , Yokoyama C. , Wu J. , Briggs M.R. , Brown M.S. , Goldstein J.L. , Wang X.
Proc. Natl. Acad. Sci. U.S.A.90:11603-11607(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-595
2.

"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E. , Wright C.L. , Edwards C.A. , Davis M.P. , Grinham J.A. , Cole C.G. , Goward M.E. , Aguado B. , Mallya M. , Mokrab Y. , Huckle E.J. , Beare D.M. , Dunham I.
Genome Biol.5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
3.

"The DNA sequence of human chromosome 22."
Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Lymph.
tissue: Skin.
5.

"SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene."
Yokoyama C. , Wang X. , Briggs M.R. , Admon A. , Wu J. , Hua X. , Goldstein J.L. , Brown M.S.
Cell75:187-197(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 91-109
6.

"Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane."
Hua X. , Sakai J. , Brown M.S. , Goldstein J.L.
J. Biol. Chem.271:10379-10384(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;MUTAGENESIS OF ASP-478; ARG-519 AND 478-ASP--ARG-481
7.

"Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins."
Pai J.-T. , Brown M.S. , Goldstein J.L.
Proc. Natl. Acad. Sci. U.S.A.93:5437-5442(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE AT ASP-468 BY CASPASES
8.

"Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning."
Duncan E.A. , Dave U.P. , Sakai J. , Goldstein J.L. , Brown M.S.
J. Biol. Chem.273:17801-17809(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY S2P;MUTAGENESIS OF ARG-479; ARG-481; LEU-484; CYS-485; 478-ASP--ARG-481; 479-ARG--ARG-481 AND 484-LEU-CYS-485
9.

"Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease."
Ye J. , Dave U.P. , Grishin N.V. , Goldstein J.L. , Brown M.S.
Proc. Natl. Acad. Sci. U.S.A.97:5123-5128(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY S2P;MUTAGENESIS OF ASN-495; PRO-496; 490-LEU-CYS-491 AND 495-ASN-PRO-496
10.

"The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage."
Irisawa M. , Inoue J. , Ozawa N. , Mori K. , Sato R.
J. Biol. Chem.284:28995-29004(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF139
11.

"The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor."
Lee S.J. , Sekimoto T. , Yamashita E. , Nagoshi E. , Nakagawa A. , Imamoto N. , Yoshimura M. , Sakai H. , Chong K.T. , Tsukihara T. , Yoneda Y.
Science302:1571-1575(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 343-403
12.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-273 AND LYS-347

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